4-(Aminomethyl)benzonitrile → HCID 21905604, compound

HRID 1247255Notes

Reaction equation

HRID 1247255 reaction equation
[CH2:1]([O:3][CH:4]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([OH:16])[CH:9]=1)[C:5]([OH:7])=O)[CH3:2].[NH2:17][CH2:18][C:19]1[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][CH:20]=1>>[C:18]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23][NH:24][C:5](=[O:7])[CH:4]([O:3][CH2:1][CH3:2])[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([OH:16])[CH:9]=2)=[CH:21][CH:20]=1)#[N:17]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 21905346HCID 21905346, compound

Product 1

HCID 21905604HCID 21905604, compound

Procedure

(RS)-Ethoxy-(3-hydroxy-4-methoxy-phenyl)-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-ethoxy-2-(3-hydroxy-4-methoxy-phenyl)-acetamide. Light yellow gum.

Sources & evidence

ORD record
ord-19cdb179005a439d8e7dcf9968af127c
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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