Hydrochloric Acid → HCID 21905747, compound

Participants

Reaction Steps

To a stirred suspension of (RS)-{5-[(4-carbamimidoyl-benzylcarbamoyl)-ethoxy-methyl]-2-methoxy-phenoxy}-acetic acid ethyl ester hydrochloride (example 18.5, 0.045 g) at rt in THF (1 ml) and water (0.5 ml) was added 1.0 N NaOH (0.2 ml). The mixture was then stirred at rt under an argon atmosphere for 3 h. The mixture waa acidified to pH 5–6 by addition of 1.0 N HCl. The THF was removed (rotavapor) and the product precipitated out from the remaining water. It was collected by filtration, washed with water and cyclohexane and dried overnight under high vacuum to give (RS)-{5-[(4-carbamimidoyl-benzylcarbamoyl)-ethoxy-methyl]-2-methoxy-phenoxy}-acetic acid (0.027 g) as a white powder. MS 416.3 ([M+H]+)

Provenance & Evidence