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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1247259Generated: October 31, 2026

4-(Aminomethyl)benzonitrile → (RS)-N-(4-cyano-benzyl)-2-(4-hydroxy-phenyl)-2-methoxy-acetamide

https://huagongshe.com/reaction/1247259

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Aminomethyl)benzonitrileHCID 82608—
Reactant2-(4-Hydroxyphenyl)-2-methoxyacetic acidHCID 18958975—
Product(RS)-N-(4-cyano-benzyl)-2-(4-hydroxy-phenyl)-2-methoxy-acetamideHCID 21905457—

Reaction Steps

(RS)-(4-Hydroxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(4-hydroxy-phenyl)-2-methoxy-acetamide. Colorless foam. MS 295.2 ([M−H]−)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07129238B2
Source datasetuspto-grants-2006_10
ORD IDord-6e8d55ad75e646458fae5ede8c4e0991
Source noteuspto-grants-2006_10