4-(Aminomethyl)benzonitrile → HCID 21905144, compound

HRID 1247262Notes

Reaction equation

HRID 1247262 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH3:11])=[CH:4][C:3]=1[CH:12]([O:16][CH3:17])[C:13]([OH:15])=O.[NH2:18][CH2:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=1>>[C:19]([C:20]1[CH:27]=[CH:26][C:23]([CH2:24][NH:25][C:13](=[O:15])[CH:12]([C:3]2[CH:4]=[C:5]([O:10][CH3:11])[C:6]([O:8][CH3:9])=[CH:7][C:2]=2[F:1])[O:16][CH3:17])=[CH:22][CH:21]=1)#[N:18]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69290852HCID 69290852, compound

Product 1

HCID 21905144HCID 21905144, compound

Procedure

(RS)-(2-Fluoro-4,5-dimethoxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-4,5-dimethoxy-phenyl)-2-methoxy-acetamide. Red foam. MS 359.2 ([M+H]+)

Sources & evidence

ORD record
ord-b49be058fd0b4a2986648d8ea2bf03a0
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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