4-(Aminomethyl)benzonitrile → HCID 21905227, compound

HRID 1247264Notes

Reaction equation

HRID 1247264 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]([O:12][CH3:13])[C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:14][CH2:15][C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1>>[C:15]([C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH:21][C:9](=[O:11])[CH:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([OH:1])[CH:3]=2)[O:12][CH3:13])=[CH:18][CH:17]=1)#[N:14]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69289011HCID 69289011, compound

Product 1

HCID 21905227HCID 21905227, compound

Procedure

(RS)-(3-Hydroxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(3-hydroxy-phenyl)-2-methoxy-acetamide. Colorless oil.

Sources & evidence

ORD record
ord-45118c8c36fe4f66a6d5805800668c06
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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