4-(Aminomethyl)benzonitrile → HCID 21905003, compound

HRID 1247268Notes

Reaction equation

HRID 1247268 reaction equation
[CH2:1]([O:3][C:4]1[C:5]([F:19])=[C:6]([CH:13]([O:17][CH3:18])[C:14]([OH:16])=O)[CH:7]=[C:8]([O:10][CH2:11][CH3:12])[CH:9]=1)[CH3:2].[NH2:20][CH2:21][C:22]1[CH:29]=[CH:28][C:25]([C:26]#[N:27])=[CH:24][CH:23]=1>>[C:21]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH:27][C:14](=[O:16])[CH:13]([C:6]2[CH:7]=[C:8]([O:10][CH2:11][CH3:12])[CH:9]=[C:4]([O:3][CH2:1][CH3:2])[C:5]=2[F:19])[O:17][CH3:18])=[CH:24][CH:23]=1)#[N:20]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69288922HCID 69288922, compound

Product 1

HCID 21905003HCID 21905003, compound

Procedure

(RS)-(3,5-Diethoxy-2-fluoro-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(3,5-diethoxy-2-fluoro-phenyl)-2-methoxy-acetamide. Light yellow oil. MS 387.3 ([M+H]+)

Sources & evidence

ORD record
ord-061d0a6aa08c4456b46e31a9d3655e2e
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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