4-(Aminomethyl)benzonitrile → HCID 21905324, compound

HRID 1247269Notes

Reaction equation

HRID 1247269 reaction equation
[CH2:1]([O:3][C:4]1[C:5]([O:17][CH2:18][CH2:19][OH:20])=[CH:6][C:7]([F:16])=[C:8]([CH:10]([O:14][CH3:15])[C:11]([OH:13])=O)[CH:9]=1)[CH3:2].[NH2:21][CH2:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1>>[C:22]([C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH:28][C:11](=[O:13])[CH:10]([C:8]2[CH:9]=[C:4]([O:3][CH2:1][CH3:2])[C:5]([O:17][CH2:18][CH2:19][OH:20])=[CH:6][C:7]=2[F:16])[O:14][CH3:15])=[CH:25][CH:24]=1)#[N:21]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69290781HCID 69290781, compound

Product 1

HCID 21905324HCID 21905324, compound

Procedure

(RS)-[5-Ethoxy-2-fluoro-4-(2-hydroxy-ethoxy)-phenyl]-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-[5-ethoxy-2-fluoro-4-(2-hydroxy-ethoxy)-phenyl]-2-methoxy-acetamide. Light yellow oil. MS 403.4 ([M+H]+)

Sources & evidence

ORD record
ord-cdb3a4a29e1547f1b8629d103b4415e1
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

Loading…