4-(Aminomethyl)benzonitrile → HCID 21905238, compound

HRID 1247274Notes

Reaction equation

HRID 1247274 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[CH:5][C:4]=1[CH:13]([O:17][CH3:18])[C:14](O)=[O:15].[NH2:21][CH2:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1>>[F:1][C:2]([F:19])([F:20])[C:3]1[CH:8]=[C:7]([C:9]([F:11])([F:12])[F:10])[CH:6]=[CH:5][C:4]=1[CH:13]([O:17][CH3:18])[C:14]([NH:28][CH2:27][C:26]1[CH:29]=[CH:30][C:23]([C:22]#[N:21])=[CH:24][CH:25]=1)=[O:15]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 21905434HCID 21905434, compound

Product 1

HCID 21905238HCID 21905238, compound

Procedure

(RS)-(2,4-Bis-trifluoromethyl-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-2-(2,4-bis-trifluoromethyl-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide. Colorless gum.

Sources & evidence

ORD record
ord-d62242784fc14e4ab5df9e72195df787
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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