4-(Aminomethyl)benzonitrile → HCID 21905389, compound

HRID 1247277Notes

Reaction equation

HRID 1247277 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH:10]([O:14][CH3:15])[C:11]([OH:13])=O.[NH2:16][CH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1>>[C:17]([C:18]1[CH:25]=[CH:24][C:21]([CH2:22][NH:23][C:11](=[O:13])[CH:10]([C:3]2[CH:4]=[C:5]([O:8][CH3:9])[CH:6]=[CH:7][C:2]=2[F:1])[O:14][CH3:15])=[CH:20][CH:19]=1)#[N:16]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 67373648HCID 67373648, compound

Product 1

HCID 21905389HCID 21905389, compound

Procedure

(RS)-(2-Fluoro-5-methoxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-5-methoxy-phenyl)-2-methoxy-acetamide. Colorless gum.

Sources & evidence

ORD record
ord-d556ac861622490fa889dcbb59148cda
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

Loading…