4-(Aminomethyl)benzonitrile → HCID 21905157, compound

HRID 1247278Notes

Reaction equation

HRID 1247278 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]([O:13][CH3:14])[C:10]([OH:12])=O.[NH2:15][CH2:16][C:17]1[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=1>>[C:16]([C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH:22][C:10](=[O:12])[CH:9]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=2[F:1])[O:13][CH3:14])=[CH:19][CH:18]=1)#[N:15]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 67373815HCID 67373815, compound

Product 1

HCID 21905157HCID 21905157, compound

Procedure

(RS)-(2,3-Difluoro-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-(2,3-difluoro-phenyl)-2-methoxy-acetamide. Off-white solid.

Sources & evidence

ORD record
ord-0cab8f38c8b748119ffb4c9049d4e012
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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