4-(Aminomethyl)benzonitrile → HCID 21905621, compound

HRID 1247280Notes

Reaction equation

HRID 1247280 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:12][CH3:13])[C:9]([OH:11])=O)=[C:4]([F:14])[CH:3]=1.[NH2:15][CH2:16][C:17]1[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:12][CH3:13])[C:9]([NH:22][CH2:21][C:20]2[CH:23]=[CH:24][C:17]([C:16]#[N:15])=[CH:18][CH:19]=2)=[O:11])=[C:4]([F:14])[CH:3]=1

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69290229HCID 69290229, compound

Product 1

HCID 21905621HCID 21905621, compound

Procedure

(RS)-(4-Bromo-2-fluoro-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-2-(4-bromo-2-fluoro-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide. Light yellow gum.

Sources & evidence

ORD record
ord-6023f0aa82804776b7e55fa7d0a44365
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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