4-(Aminomethyl)benzonitrile → HCID 21905481, compound

HRID 1247282Notes

Reaction equation

HRID 1247282 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:12][CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=O)=[C:4]([F:16])[CH:3]=1.[NH2:17][CH2:18][C:19]1[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][CH:20]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:12][CH2:13][CH2:14][CH3:15])[C:9]([NH:24][CH2:23][C:22]2[CH:25]=[CH:26][C:19]([C:18]#[N:17])=[CH:20][CH:21]=2)=[O:11])=[C:4]([F:16])[CH:3]=1

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 21905408HCID 21905408, compound

Product 1

HCID 21905481HCID 21905481, compound

Procedure

(RS)-(4-Bromo-2-fluoro-phenyl)-propoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-2-(4-bromo-2-fluoro-phenyl)-N-(4-cyano-benzyl)-2-propoxy-acetamide. Colorless oil. MS 405.3 ([M+H]+)

Sources & evidence

ORD record
ord-62450fba33a941fea60a3e5fdf5641d4
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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