4-(Aminomethyl)benzonitrile → HCID 21904906, compound

HRID 1247285Notes

Reaction equation

HRID 1247285 reaction equation
[CH3:1][N:2]([CH3:15])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([O:13][CH3:14])[C:10]([OH:12])=O)=[CH:5][CH:4]=1.[NH2:16][CH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1>>[C:17]([C:18]1[CH:25]=[CH:24][C:21]([CH2:22][NH:23][C:10](=[O:12])[CH:9]([C:6]2[CH:5]=[CH:4][C:3]([N:2]([CH3:1])[CH3:15])=[CH:8][CH:7]=2)[O:13][CH3:14])=[CH:20][CH:19]=1)#[N:16]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69290641HCID 69290641, compound

Product 1

HCID 21904906HCID 21904906, compound

Procedure

(RS)-(4-Dimethylamino-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(4-dimethylamino-phenyl)-2-methoxy-acetamide. Off-white solid. MS 324.2 ([M+H]+)

Sources & evidence

ORD record
ord-d1447946a8d0443e95c6e3ed7884322f
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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