4-(Aminomethyl)benzonitrile → HCID 21905002, compound

HRID 1247289Notes

Reaction equation

HRID 1247289 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([O:15][CH3:16])[C:12]([OH:14])=O)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[NH2:17][CH2:18][C:19]1[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][CH:20]=1>>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([CH:11]([O:15][CH3:16])[C:12]([NH:24][CH2:23][C:22]2[CH:25]=[CH:26][C:19]([C:18]#[N:17])=[CH:20][CH:21]=2)=[O:14])=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 57582496HCID 57582496, compound

Product 1

HCID 21905002HCID 21905002, compound

Procedure

(RS)-(4-Acetylamino-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-2-(4-acetylamino-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide. Off-white, amorphous solid. MS 338.3([M+H]+)

Sources & evidence

ORD record
ord-ba9437267cd5459fa732e467a3227c3c
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

Loading…