4-(Aminomethyl)benzonitrile → HCID 21905331, compound

HRID 1247290Notes

Reaction equation

HRID 1247290 reaction equation
[CH3:1][O:2][CH:3]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=1)[C:4]([OH:6])=O.[NH2:18][CH2:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=1>>[C:19]([C:20]1[CH:27]=[CH:26][C:23]([CH2:24][NH:25][C:4](=[O:6])[CH:3]([O:2][CH3:1])[C:7]2[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=2)=[CH:22][CH:21]=1)#[N:18]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 21905685HCID 21905685, compound

Product 1

HCID 21905331HCID 21905331, compound

Procedure

(RS)-Methoxy-(4-trifluoromethoxy-phenyl)-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-methoxy-2-(4-trifluoromethoxy-phenyl)-acetamide. Light blue semisolid. MS 365.2 ([M+H]+)

Sources & evidence

ORD record
ord-d812b6ea314e47cd9e1bcb199bcd1f5f
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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