4-(Aminomethyl)benzonitrile → HCID 21905226, compound

HRID 1247292Notes

Reaction equation

HRID 1247292 reaction equation
[CH3:1][O:2][CH:3]([C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:17][CH3:18])[CH:13]=2)[CH:8]=1)[C:4]([OH:6])=O.[NH2:19][CH2:20][C:21]1[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=1>>[C:20]([C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH:26][C:4](=[O:6])[CH:3]([O:2][CH3:1])[C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:17][CH3:18])[CH:13]=3)[CH:8]=2)=[CH:23][CH:22]=1)#[N:19]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 21905632HCID 21905632, compound

Product 1

HCID 21905226HCID 21905226, compound

Procedure

(RS)-Methoxy-(6-methoxy-naphthalen-2-yl)-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-methoxy-2-(6-methoxy-naphthalen-2-yl)-acetamide. Off-white foam. MS 361.2 ([M+H]+)

Sources & evidence

ORD record
ord-8cb89a62a58f4291b4baa7c9344f328b
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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