4-(Aminomethyl)benzonitrile → HCID 21905336, compound

HRID 1247301Notes

Reaction equation

HRID 1247301 reaction equation
[CH3:1][C:2]1([CH3:18])[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH:12]([O:16][CH3:17])[C:13]([OH:15])=O)[CH:8]=2)[O:3]1.[NH2:19][CH2:20][C:21]1[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=1>>[C:20]([C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH:26][C:13](=[O:15])[CH:12]([C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[O:3][C:2]([CH3:1])([CH3:18])[CH2:11][CH2:10]3)[O:16][CH3:17])=[CH:23][CH:22]=1)#[N:19]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69288826HCID 69288826, compound

Product 1

HCID 21905336HCID 21905336, compound

Procedure

(RS)-(2,2-Dimethyl-chroman-6-yl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-(2,2-dimethyl-chroman-6-yl)-2-methoxy-acetamide. Off-white semi-solid. MS 365.2 ([M+H]+)

Sources & evidence

ORD record
ord-7c2697e27f1c49aaa2a534ed7ba687cb
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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