4-(Aminomethyl)benzonitrile → HCID 21905384, compound

HRID 1247303Notes

Reaction equation

HRID 1247303 reaction equation
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:15]([O:19][CH3:20])[C:16]([OH:18])=O)[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:21][CH2:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1>>[C:22]([C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH:28][C:16](=[O:18])[CH:15]([C:9]2[CH:10]=[CH:11][C:12]([O:13][CH3:14])=[C:7]([O:6][CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)[CH:8]=2)[O:19][CH3:20])=[CH:25][CH:24]=1)#[N:21]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69292817HCID 69292817, compound

Product 1

HCID 21905384HCID 21905384, compound

Procedure

(RS)-(3-Cyclopentyloxy-4-methoxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(3-cyclopentyloxy-4-methoxy-phenyl)-2-methoxy-acetamide. Colorless solid.

Sources & evidence

ORD record
ord-68b11693010b403f82c4de135708beaa
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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