4-(Aminomethyl)benzonitrile → HCID 21904996, compound

HRID 1247304Notes

Reaction equation

HRID 1247304 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]([O:14][CH3:15])[C:11]([OH:13])=O.[NH2:16][CH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]([O:14][CH3:15])[C:11]([NH:23][CH2:22][C:21]1[CH:24]=[CH:25][C:18]([C:17]#[N:16])=[CH:19][CH:20]=1)=[O:13]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69288999HCID 69288999, compound

Product 1

HCID 21904996HCID 21904996, compound

Procedure

(RS)-(2-Chloro-4-methoxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-2-(2-chloro-4-methoxy-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide. Light yellow oil. MS 345.2 ([M+H]+)

Sources & evidence

ORD record
ord-ec9069c55edd4db8a320d20453c7bff0
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

Loading…