HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Aminomethyl)benzonitrile → (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Aminomethyl)benzonitrile | HCID 82608 | — |
| Reactant | (RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid | HCID 69288907 | — |
| Product | (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide | HCID 21905429 | — |
Reaction Steps
(RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide. Light yellow amorphous solid. MS 347.1 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129238B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-b17e8584685b47bba5b83ce9c41f25a6 |
| Source note | uspto-grants-2006_10 |