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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1247309Generated: October 31, 2026

2-Fluoro-4-hydroxybenzaldehyde → 4-(Benzyloxy)-2-fluorobenzaldehyde

https://huagongshe.com/reaction/1247309

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-4-hydroxybenzaldehydeHCID 587246—
ReactantBenzylbromide potassium carbonateHCID 86593042—
SolventDimethylformamideHCID 6228—
Product4-(Benzyloxy)-2-fluorobenzaldehydeHCID 12136989—

Reaction Steps

In analogy to example 16.4, 2-fluoro-4-hydroxy-benzaldehyde (CAS-No: 348-27-6) was alkylated with benzylbromide/potassium carbonate in DMF to give 4-benzyloxy-2-fluoro-benzaldehyde. Off-white solid. MS 230.1 ([M+H]+)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07129238B2
Source datasetuspto-grants-2006_10
ORD IDord-899411a6c6b6414f8f8628ef99a0ebe7
Source noteuspto-grants-2006_10