4-(Aminomethyl)benzonitrile → HCID 21905330, compound

HRID 1247311Notes

Reaction equation

HRID 1247311 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[CH:9]([O:13][CH3:14])[C:10]([OH:12])=O.[NH2:15][CH2:16][C:17]1[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=1>>[C:16]([C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH:22][C:10](=[O:12])[CH:9]([C:3]2[CH:4]=[CH:5][C:6]([OH:8])=[CH:7][C:2]=2[F:1])[O:13][CH3:14])=[CH:19][CH:18]=1)#[N:15]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 45115839HCID 45115839, compound

Product 1

HCID 21905330HCID 21905330, compound

Procedure

(RS)-(2-Fluoro-4-hydroxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-4-hydroxy-phenyl)-2-methoxy-acetamide. White solid. MS 315.1 ([M+H]+)

Sources & evidence

ORD record
ord-b5fa45bf1fa0425eaef85ef54db7a63f
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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