HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 21904891, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 4-Fluorophenethyl Alcohol | HCID 82068 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | HCID 21905330 | HCID 21905330 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 21904891 | HCID 21904891 | — |
Reaction Steps
In analogy to example 22.1, (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-4-hydroxy-phenyl)-2-methoxy-acetamide (example 70.4) was reacted with 4-fluorophenethyl alcohol, diethyl azodicarboxylate and triphenyl-phosphine in THF to give (RS)-N-(4-cyano-benzyl)-2-{2-fluoro-4-[2-(4-fluoro-phenyl)-ethoxy]-phenyl}-2-methoxy-acetamide. Colorless oil. MS 437.3 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129238B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-b4fbec2e0a2d472c9f3bf284d1ba3190 |
| Source note | uspto-grants-2006_10 |