4-Bromopyridinium chloride → HCID 21905568, compound

HRID 1247316Notes

Reaction equation

HRID 1247316 reaction equation
[C:1]([C:3]1[CH:31]=[CH:30][C:6]([CH2:7][NH:8][C:9](=[O:29])[CH:10]([C:13]2[CH:18]=[CH:17][C:16](B3OC(C)(C)C(C)(C)O3)=[CH:15][C:14]=2[F:28])[O:11][CH3:12])=[CH:5][CH:4]=1)#[N:2].Cl.Br[C:34]1[CH:39]=[CH:38][N:37]=[CH:36][CH:35]=1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][C:9](=[O:29])[CH:10]([C:13]2[CH:18]=[CH:17][C:16]([C:34]3[CH:39]=[CH:38][N:37]=[CH:36][CH:35]=3)=[CH:15][C:14]=2[F:28])[O:11][CH3:12])=[CH:30][CH:31]=1)#[N:2]

Participants

3

Reactant 2

HCID 881004-Bromopyridinium chlorideHCID 21905721HCID 21905721, compound

Product 1

HCID 21905568HCID 21905568, compound

Procedure

In analogy to example 57.1 (RS)-N-(4-cyano-benzyl)-2-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-2-methoxy-acetamide (example 73.1) was reacted with 4-bromopyridine, hydrochloride to give (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-4-pyridin-4-yl-phenyl)-2-methoxy-acetamide. Light brown amorphous solid. MS 376.3 ([M+H]+)

Sources & evidence

ORD record
ord-ce6dcaf1bd5a4dbaa7ca70ae8490737e
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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