4-(Aminomethyl)benzonitrile → HCID 21905102, compound

HRID 1247317Notes

Reaction equation

HRID 1247317 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:14])=[C:6]([CH:8]([O:12][CH3:13])[C:9]([OH:11])=O)[CH:7]=1.[NH2:15][CH2:16][C:17]1[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:14])=[C:6]([CH:8]([O:12][CH3:13])[C:9]([NH:22][CH2:21][C:20]2[CH:23]=[CH:24][C:17]([C:16]#[N:15])=[CH:18][CH:19]=2)=[O:11])[CH:7]=1

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69290394HCID 69290394, compound

Product 1

HCID 21905102HCID 21905102, compound

Procedure

(RS)-(5-Bromo-2-fluoro-phenyl)-methoxy-acetic acid was reacted with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-2-(5-bromo-2-fluoro-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide. Colorless solid. MS 377.2 ([M+H]+)

Sources & evidence

ORD record
ord-fdf8870c5e76484e9a87f48ae26cb3e6
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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