4-(Aminomethyl)benzonitrile → HCID 21905409, compound

HRID 1247319Notes

Reaction equation

HRID 1247319 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH:9]([O:13][CH3:14])[C:10]([OH:12])=O.[NH2:15][CH2:16][C:17]1[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=1>>[C:16]([C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH:22][C:10](=[O:12])[CH:9]([C:3]2[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=2[F:1])[O:13][CH3:14])=[CH:19][CH:18]=1)#[N:15]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69290603HCID 69290603, compound

Product 1

HCID 21905409HCID 21905409, compound

Procedure

(RS)-(2-Fluoro-5-methyl-phenyl)-methoxy-acetic acid was reacted with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-5-methyl-phenyl)-2-methoxy-acetamide. Colorless amorphous solid. MS 313.2 ([M+H]+)

Sources & evidence

ORD record
ord-550ccd54a1e240398ae86d7c3db1b86f
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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