4-(Aminomethyl)benzonitrile → HCID 21905042, compound

HRID 1247320Notes

Reaction equation

HRID 1247320 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[CH:9]([O:13][CH3:14])[C:10]([OH:12])=O.[NH2:15][CH2:16][C:17]1[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=1>>[C:16]([C:17]1[CH:24]=[CH:23][C:20]([CH2:21][NH:22][C:10](=[O:12])[CH:9]([C:3]2[C:4]([OH:8])=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[O:13][CH3:14])=[CH:19][CH:18]=1)#[N:15]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 45115838HCID 45115838, compound

Product 1

HCID 21905042HCID 21905042, compound

Procedure

(RS)-(2-Fluoro-6-hydroxy-phenyl)-methoxy-acetic acid was reacted with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-6-hydroxy-phenyl)-2-methoxy-acetamide. Colorless solid. MS 315.1 ([M+H]+)

Sources & evidence

ORD record
ord-52a4c0e3fe0745d1bf281c90de44d4cf
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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