4-(Aminomethyl)benzonitrile → HCID 21905686, compound
Reaction equation
[Br:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:5])=O.[NH2:12][CH2:13][C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=1>>[Br:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([NH:19][CH2:18][C:17]1[CH:20]=[CH:21][C:14]([C:13]#[N:12])=[CH:15][CH:16]=1)=[O:5]Participants
3
Procedure
α-Bromophenylacetic acid was reacted with 4-aminomethyl benzonitrile according to general procedure C to give (RS)-2-bromo-N-(4-cyano-benzyl)-2-phenyl-acetamide. White solid. MS 329.1 ([M+H]+)
Sources & evidence
- ORD record
- ord-2b1c850ab8f64394b4803b9c825c0ef2
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07129238B2
Reaction notes
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