Acetyl chloride → HCID 21905107, compound

Participants

Reaction Steps

A solution of (RS)-2-amino-N-(4-cyano-benzyl)-2-phenyl-acetamide (0.1 g) in dichloromethane (5 ml) was cooled to 0° C. and treated with triethylamine (58 μl) and acetyl chloride (28 μl). The reaction mixture was stirred at rt for 1 hr, then diluted with dichloromethane, washed with 1N HCl and brine. The organic layer was dried over MgSO4, filtered and concentrated. The product was isolated by chromatography (silica gel, gradient dichloromethane=>dichloromethane/MeOH 9:1) to give (RS)-2-acetylamino-N-(4-cyano-benzyl)-2-phenyl-acetamide (98 mg). Off-white solid. MS 308.2 ([M+H]+)

Provenance & Evidence