4-(Aminomethyl)benzonitrile → (RS)-N-(4-cyano-benzyl)-2-methoxy-2-pyridin-2-yl-acetamide

HRID 1247329Notes

Reaction equation

HRID 1247329 reaction equation
[CH3:1][O:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[C:4]([OH:6])=O.[NH2:13][CH2:14][C:15]1[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=1>>[C:14]([C:15]1[CH:22]=[CH:21][C:18]([CH2:19][NH:20][C:4](=[O:6])[CH:3]([O:2][CH3:1])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)=[CH:17][CH:16]=1)#[N:13]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 21905598(RS)-Methoxy-pyridin-2-yl-acetic acid

Product 1

HCID 21905519(RS)-N-(4-cyano-benzyl)-2-methoxy-2-pyridin-2-yl-acetamide

Procedure

(RS)-Methoxy-pyridin-2-yl-acetic acid was reacted with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-methoxy-2-pyridin-2-yl-acetamide. Brown oil. MS 282.2 ([M+H]+)

Sources & evidence

ORD record
ord-dfba3a65ccc34900b005bbe7dc3473b3
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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