4-(Aminomethyl)benzonitrile → HCID 21905089, compound

HRID 1247330Notes

Reaction equation

HRID 1247330 reaction equation
[CH3:1][O:2][C:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[C:4]([OH:6])=O.[NH2:14][CH2:15][C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1>>[C:15]([C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH:21][C:4](=[O:6])[C:3]([O:2][CH3:1])([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH3:7])=[CH:18][CH:17]=1)#[N:14]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 3448952-methoxy-2-phenylpropanoic acid

Product 1

HCID 21905089HCID 21905089, compound

Procedure

(RS)-2-Methoxy-2-phenyl-propionic acid was reacted with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-methoxy-2-phenyl-propionamide. Off-white, waxy solid. MS 295.0 ([M+H]+)

Sources & evidence

ORD record
ord-5098d19e26124b6389214be9d30fdf77
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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