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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1247332Generated: November 1, 2026

Iodoacetamide → HCID 21905298, compound

https://huagongshe.com/reaction/1247332

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodoacetamideHCID 3727—
ReactantPotassium CarbonateHCID 11430—
ReactantHCID 21905042HCID 21905042—
SolventDimethylformamideHCID 6228—
ProductHCID 21905298HCID 21905298—

Reaction Steps

In analogy to example 16.4 (RS)-N-(4-cyano-benzyl)-2-(2-fluoro-6-hydroxy-phenyl)-2-methoxy-acetamide (example 80.4) was reacted with iodo acetamide in the presence of potassium carbonate in DMF to give 2-(2-carbamoylmethoxy-6-fluoro-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide. Solid. MS 372.2 ([M+H]+)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07129238B2
Source datasetuspto-grants-2006_10
ORD IDord-d54ac0dc4b5e4609b5903d02e6c84000
Source noteuspto-grants-2006_10