4-(Aminomethyl)benzonitrile → HCID 21905180, compound

HRID 1247334Notes

Reaction equation

HRID 1247334 reaction equation
[C:1]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:6]=[CH:5][C:4]([C:7]([O:12][CH2:13][CH3:14])([CH3:11])[C:8]([OH:10])=O)=[CH:3][CH:2]=1.[NH2:21][CH2:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1>>[C:1]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:6]=[CH:5][C:4]([C:7]([O:12][CH2:13][CH3:14])([CH3:11])[C:8]([NH:28][CH2:27][C:26]2[CH:29]=[CH:30][C:23]([C:22]#[N:21])=[CH:24][CH:25]=2)=[O:10])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 21905467HCID 21905467, compound

Product 1

HCID 21905180HCID 21905180, compound

Procedure

(RS)-2-Biphenyl-4-yl-2-ethoxy-propionic acid was coupled with 4-aminomethyl benzonitrile to give (RS)-2-biphenyl-4-yl-N-(4-cyano-benzyl)-2-ethoxy-propionamide according to general procedure C. Colorless solid. MS 385.1 ([M+H]+)

Sources & evidence

ORD record
ord-c003aef2c86946339013b4c80c4665d4
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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