4-(Aminomethyl)benzonitrile → HCID 69290097, compound

HRID 1247335Notes

Reaction equation

HRID 1247335 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[C:19]([O:21][CH2:22][CH3:23])[CH:18]=[C:17]([CH:24]([C:27]([OH:29])=O)[O:25][CH3:26])[C:16]=2[F:30])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:31][CH2:32][C:33]1[CH:40]=[CH:39][C:36]([C:37]#[N:38])=[CH:35][CH:34]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[CH:20]=[C:19]([O:21][CH2:22][CH3:23])[CH:18]=[C:17]([CH:24]([C:27](=[O:29])[NH:38][CH2:37][C:36]3[CH:39]=[CH:40][C:33]([C:32]#[N:31])=[CH:34][CH:35]=3)[O:25][CH3:26])[C:16]=2[F:30])[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 69288788HCID 69288788, compound

Product 1

HCID 69290097HCID 69290097, compound

Procedure

(RS)-4-[3-(Carboxy-methoxy-methyl)-5-ethoxy-2-fluoro-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester was coupled with 4-aminomethyl benzonitrile to give (RS)-4-{3-[(4-cyano-benzylcarbamoyl)-methoxy-methyl]-5-ethoxy-2-fluoro-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester according to general procedure B. Yellow oil. MS 564.4 ([M+Na]+)

Sources & evidence

ORD record
ord-26aba12447f74529a029d2bcaa4a421e
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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