Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Aminomethyl)-3-chlorobenzonitrile → (RS)-N-(2-chloro-4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Aminomethyl)-3-chlorobenzonitrile | HCID 4089788 | — |
| 반응물 | (RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid | HCID 69288907 | — |
| 생성물 | (RS)-N-(2-chloro-4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide | HCID 21905691 | — |
반응 단계
(RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid, described in example 66.1 was coupled with 4-aminomethyl-3-chlorobenzonitrile (CAS 202521-97-9) according to general procedure C to give (RS)-N-(2-chloro-4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide. Light yellow oil. MS 379.2 ([M−H]−)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07129238B2 |
| 출처 데이터셋 | uspto-grants-2006_10 |
| ORD ID | ord-291a0b548b584663bc50a013d43e4751 |
| 출처 메모 | uspto-grants-2006_10 |