(RS)-Ethoxy-(2-fluoro-4-methoxy-phenyl)-acetic acid → (RS)-N-(3-chloro-4-cyano-benzyl)-2-ethoxy-2-(2-fluoro-4-methoxy-phenyl)-acetamide

HRID 1247343Notes

Reaction equation

HRID 1247343 reaction equation
[CH2:1]([O:3][CH:4]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:9]=1[F:16])[C:5]([OH:7])=O)[CH3:2].[NH2:17][CH2:18][C:19]1[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[C:21]([Cl:27])[CH:20]=1>>[Cl:27][C:21]1[CH:20]=[C:19]([CH:26]=[CH:25][C:22]=1[C:23]#[N:24])[CH2:18][NH:17][C:5](=[O:7])[CH:4]([O:3][CH2:1][CH3:2])[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:9]=1[F:16]

Participants

3

Reactant 2

HCID 21904991(RS)-Ethoxy-(2-fluoro-4-methoxy-phenyl)-acetic acidHCID 219057174-(Aminomethyl)-2-chlorobenzonitrile

Product 1

HCID 21905421(RS)-N-(3-chloro-4-cyano-benzyl)-2-ethoxy-2-(2-fluoro-4-methoxy-phenyl)-acetamide

Procedure

(RS)-Ethoxy-(2-fluoro-4-methoxy-phenyl)-acetic acid, described in example 63.1 was coupled with 4-aminomethyl-2-chlorobenzonitrile (CAS 202522-15-4) according to general procedure C to give (RS)-N-(3-chloro-4-cyano-benzyl)-2-ethoxy-2-(2-fluoro-4-methoxy-phenyl)-acetamide. Yellow oil. MS 377.2 ([M+H]+)

Sources & evidence

ORD record
ord-a39c4a82238048908a9f73402b122545
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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