Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminomethyl-3-hydroxy-benzonitrile hydrochloride → (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminomethyl-3-hydroxy-benzonitrile hydrochloride | HCID 21905683 | — |
| 반응물 | (RS)-(2,6-Difluoro-4-methoxy-phenyl)-ethoxy-acetic acid | HCID 21905754 | — |
| 생성물 | (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide | HCID 21905119 | — |
반응 단계
(RS)-(2,6-Difluoro-4-methoxy-phenyl)-ethoxy-acetic acid (example 101.3) was coupled with 4-aminomethyl-3-hydroxy-benzonitrile hydrochloride (example 110.2) according to general procedure B to give (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide. Colorless foam. MS 375.4 ([M−H]−)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07129238B2 |
| 출처 데이터셋 | uspto-grants-2006_10 |
| ORD ID | ord-48b55bf0af7b44fba7384ab585c7ec25 |
| 출처 메모 | uspto-grants-2006_10 |