HuagongsheHuagongshe Chemistry Print Report · For research reference only
(RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide → (RS)-N-(2-carbamoylmethoxy-4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide | HCID 21905119 | — |
| Reactant | Iodoacetamide cesium carbonate | HCID 86593045 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (RS)-N-(2-carbamoylmethoxy-4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide | HCID 21905465 | — |
Reaction Steps
In analogy to example 16.4, (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide was alkylated with iodoacetamide/cesium carbonate in DMF to give (RS)-N-(2-carbamoylmethoxy-4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide as a colorless solid. MS 434.3 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129238B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-d2e1068f848c4fe28f7b77082584c1ec |
| Source note | uspto-grants-2006_10 |