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4-Aminomethyl-3-hydroxy-benzonitrile hydrochloride → (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminomethyl-3-hydroxy-benzonitrile hydrochloride | HCID 21905683 | — |
| 反応物 | (RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid | HCID 69288907 | — |
| 生成物 | (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide | HCID 21905527 | — |
反応手順
(RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid (example 66.1) was coupled with 4-aminomethyl-3-hydroxy-benzonitrile hydrochloride (example 110.2) according to general procedure C to give (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide. Colorless foam. MS 361.1 ([M−H]−)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07129238B2 |
| 出典データセット | uspto-grants-2006_10 |
| ORD ID | ord-0e2f3acef41b42f4b8f8bd1ee1d87f48 |
| 出典メモ | uspto-grants-2006_10 |