HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Aminomethyl-3-(2,2,2-trifluoro-ethoxy)-benzonitrile → (RS)-N-[4-cyano-2-(2,2,2-trifluoro-ethoxy)-benzyl]-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Aminomethyl-3-(2,2,2-trifluoro-ethoxy)-benzonitrile | HCID 21905243 | — |
| Edukt | (RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid | HCID 69288907 | — |
| Produkt | (RS)-N-[4-cyano-2-(2,2,2-trifluoro-ethoxy)-benzyl]-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide | HCID 21904880 | — |
Reaktionsschritte
(RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid (example 66.1) was coupled with 4-aminomethyl-3-(2,2,2-trifluoro-ethoxy)-benzonitrile according to general procedure B to give (RS)-N-[4-cyano-2-(2,2,2-trifluoro-ethoxy)-benzyl]-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide. Colorless solid. MS 445.0 ([M+H]+)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07129238B2 |
| Quelldatensatz | uspto-grants-2006_10 |
| ORD ID | ord-772dc6130b07430d8c8225b489af67b2 |
| Quellennotiz | uspto-grants-2006_10 |