HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → (RS)-[3-(tert-Butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-methoxy-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | (RS)-[3-(tert-butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-hydroxy-acetic acid ethyl ester | HCID 69290212 | — |
| Product | (RS)-[3-(tert-Butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-methoxy-acetic acid ethyl ester | HCID 69291101 | — |
Reaction Steps
(RS)-[3-(tert-Butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-methoxy-acetic acid ethyl ester was prepared in analogy to example 173 from (RS)-[3-(tert-butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-hydroxy-acetic acid ethyl ester and iodomethane. Yellowish oil. MS 484.2 (4, [M+]+); 427.1 (29, [M−tBu]+); 411.2 (14, [M−COOEt]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129238B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-08273d5bbfa041e29246b075e0747686 |
| Source note | uspto-grants-2006_10 |