Lithium hydroxide, monohydrate → HCID 69292797, compound

Participants

Reaction Steps

A solution of (RS)-3-[(4-cyano-benzylcarbamoyl)-methoxy-methyl]-2,4-difluoro-benzoic acid methyl ester (2.05 g) and LiOH.H2O (241 mg) in THF/MeOH/H2O 1:1:0.5 (75 ml) was stirred 1 h at rt. The organic solvents were evaporated, ice cold H2O (50 ml) was added and the pH was lowered (pH=2) by addition of 2 N aq. HCl sol. The product was extracted with AcOEt (2×120 ml). The organic layers were washed with brine (100 ml), combined and dried over Na2SO4. Evaporation of the solvent yielded 1.80 g of (RS)-3-[(4-cyano-benzylcarbamoyl)-methoxy-methyl]-2,4-difluoro-benzoic acid. White solid. MS 359.4 ([M−H]).

Provenance & Evidence