Acetic Acid → HCID 21905052, compound

Participants

Reaction Steps

A solution of (RS)-2-[2,6-difluoro-3-(morpholine-4-carbonyl)-phenyl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-2-methoxy-acetamide (125 mg) was hydrogenated 2 days at rt and 1 atm H2 in presence of 10% Pd/C (13 mg) and AcOH (143 mg). The catalyst was filtered away and the solvent was evaporated to obtain 115 mg of (RS)-N-(4-carbamimidoyl-benzyl)-2-[2,6-difluoro-3-(morpholine-4-carbonyl)-phenyl]-2-methoxy-acetamide acetate. Off-white solid, MS 447.1 ([M+H]+).

Provenance & Evidence