Ethyl bromoacetate → HCID 69288789, compound

Participants

Reaction Steps

In analogy to example 247.1, (RS)-2-(4-bromo-2,6-difluoro-phenyl)-N-(4-cyano-benzyl)-2-ethoxy-acetamide (example 248.1) was reacted with 3-hydroxyphenylboronic acid. The product of this reaction was alkylated with ethylbromoacetate and cesiumcarbonate in DMF (analogous to example 16.4) to give (RS)-{4′-[(4-cyano-benzylcarbamoyl)-ethoxy-methyl]-3′,5′-difluoro-biphenyl-3-yloxy}-acetic acid ethyl ester. Colorless oil. MS 509.1 ([M+H]+)

Provenance & Evidence