Sodium borohydride → HCID 21905518, compound

Participants

Reaction Steps

To a suspension of (RS)-N-(4-cyano-benzyl)-2-(3,5-difluoro-2′-formyl-biphenyl-4-yl)-2-ethoxy-acetamide (500 mg) in EtOH (1.2 ml) at 0° C. was added sodium borohydride (91 mg). After 5 min the ice bath was removed. Ice water was added and the mixture was extracted with EtOAc. The organic phase was dried, filtered and concentrated. The product was purified by chromatography (SiO2, cyclohexane/EtOAc 1:2=>EtOAc) to give (RS)-N-(4-cyano-benzyl)-2-(3,5-difluoro-2′-hydroxymethyl-biphenyl-4-yl)-2-ethoxy-acetamide (413 mg). Colorless solid. MS 437.0 ([M+H]+)

Provenance & Evidence