Isopropyl iodide → HCID 21905006, compound

HRID 1247416Notes

Reaction equation

[C:1]([C:3]1[CH:25]=[CH:24][C:6]([CH2:7][NH:8][C:9](=[O:23])[CH:10]([C:14]2[C:19]([F:20])=[CH:18][C:17]([OH:21])=[CH:16][C:15]=2[F:22])[O:11][CH2:12][CH3:13])=[CH:5][CH:4]=1)#[N:2].[CH:26](I)([CH3:28])[CH3:27]>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][C:9](=[O:23])[CH:10]([C:14]2[C:15]([F:22])=[CH:16][C:17]([O:21][CH:26]([CH3:28])[CH3:27])=[CH:18][C:19]=2[F:20])[O:11][CH2:12][CH3:13])=[CH:24][CH:25]=1)#[N:2]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 21905325HCID 21905325, compound

Product 1

HCID 21905006HCID 21905006, compound

Procedure

In analogy to example 16.4 (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-4-hydroxy-phenyl)-2-ethoxy-acetamide was reacted with isopropyl iodide to give (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-4-isopropoxy-phenyl)-2-ethoxy-acetamide. Colorless oil. MS 387.1 ([M−H]−)

Sources & evidence

ORD record: ord-193268bf5de44822add2ad846e6f9d8a
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129238B2

Reaction notes

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