Acetyl chloride → HCID 21905590, compound

HRID 1247423Notes

Reaction equation

[NH2:1][C:2]1[C:3]([F:24])=[C:4]([CH:9]([O:22][CH3:23])[C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]#[N:21])=[CH:16][CH:15]=2)=[O:11])[C:5]([F:8])=[CH:6][CH:7]=1.[C:25](Cl)(=[O:27])[CH3:26]>>[C:25]([NH:1][C:2]1[C:3]([F:24])=[C:4]([CH:9]([O:22][CH3:23])[C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]#[N:21])=[CH:16][CH:15]=2)=[O:11])[C:5]([F:8])=[CH:6][CH:7]=1)(=[O:27])[CH3:26]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 21905257HCID 21905257, compound

Product 1

HCID 21905590HCID 21905590, compound

Procedure

In analogy to example 87.2 (RS)-2-(3-amino-2,6-difluoro-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide (example 30.5) was reacted with acetyl chloride to give (RS)-2-(3-acetylamino-2,6-difluoro-phenyl)-N-(4-cyano-benzyl)-2-methoxy-acetamide as white foam.

Sources & evidence

ORD record: ord-5eebb599a7bd4a93978565de6f1d3d7e
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07129238B2

Reaction notes

Loading…