4-(Aminomethyl)benzonitrile → HCID 21905731, compound

HRID 1247425Notes

Reaction equation

HRID 1247425 reaction equation
[F:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[C:4]([F:10])[C:3]=1[CH:11]([O:15][CH2:16][CH3:17])[C:12]([OH:14])=O.[NH2:18][CH2:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=1>>[C:19]([C:20]1[CH:27]=[CH:26][C:23]([CH2:24][NH:25][C:12](=[O:14])[CH:11]([C:3]2[C:4]([F:10])=[CH:5][CH:6]=[C:7]([CH:8]=[O:9])[C:2]=2[F:1])[O:15][CH2:16][CH3:17])=[CH:22][CH:21]=1)#[N:18]

Participants

3

Reactant 2

HCID 826084-(Aminomethyl)benzonitrileHCID 21905135α-Ethoxy-2,6-difluoro-3-formylbenzeneacetic acid

Product 1

HCID 21905731HCID 21905731, compound

Procedure

According to general procedure B (RS)-(2,6-difluoro-3-formyl-phenyl)-ethoxy-acetic acid was reacted with 4-aminomethyl benzonitrile to give (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-formyl-phenyl)-2-ethoxy-acetamide. Amorphous off-white solid. MS 359.2 ([M+H]+)

Sources & evidence

ORD record
ord-ae25aa0e578d4b54a4c62c27737fd0a4
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Reaction notes

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