Sodium borohydride → HCID 21905675, compound

Participants

Reaction Steps

A suspension of (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-formyl-phenyl)-2-ethoxy-acetamide (300 mg) in EtOH (1 ml) was treated with NaBH4 (66 mg) at 0°. The reaction mixture was stirred for 4 hrs at rt, then poured onto ice and extracted with EtOAc. The organic layers were combined, dried over MgSO4, filtrated and concentrated. The crude product was isolated by flash chromatography (CH2CH12=>CH2C2-12MeOH 4:1) to give (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxymethyl-phenyl)-2-ethoxy-acetamide (174 mg) as amourphous white solid. MS 361.3 ([M+H]+)

Provenance & Evidence