HuagongsheHuagongshe Chemistry Print Report · For research reference only
(RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid → (RS)-2-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-N-(4-cyano-2,6-difluoro-benzyl)-2-ethoxy-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid | HCID 21905479 | — |
| Reactant | 4-(Aminomethyl)-3,5-difluorobenzonitrile hydrochloride | HCID 21905559 | — |
| Product | (RS)-2-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-N-(4-cyano-2,6-difluoro-benzyl)-2-ethoxy-acetamide | HCID 21905192 | — |
Reaction Steps
According to general procedure C, (RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid (intermediate from example 334.4, contains 2 equivalent of NaCl) was reacted with 4-aminomethyl-3,5-difluoro-benzonitrile hydrochloride (example 318.1) to give (RS)-2-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-N-(4-cyano-2,6-difluoro-benzyl)-2-ethoxy-acetamide as off-white solid. MS 459.6 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07129238B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-021d86cb3c7a472c976bd40ebbd0af70 |
| Source note | uspto-grants-2006_10 |